Organophosphate Poisoning–Induced Intermediate Syndrome: Can Electrophysiological Changes Help Predict Outcome?
نویسنده
چکیده
Organophosphate (OP) pesticides contribute to a substantial burden of mortality and morbidity from selfpoisoning, particularly in developing countries. Such poisonings are associated with several syndromes, including acute cholinergic crises, the intermediate syndrome (IMS), and organophosphate-induced delayed neuropathy. In a study published in PLoS Medicine, Jayawardane and colleagues begin to scientifically characterize a specific constellation of signs and symptoms seen after poisoning with organophosphates [1]. Specifically, they aim to define the pathophysiology of IMS, which was initially described in 1987 as an illness occurring after the resolution of acute cholinergic crises and associated with proximal muscle weakness [2]. Since this seminal article was published, there has been tremendous controversy in the toxicology world concerning the true definition and existence of IMS as an isolated entity [3,4]. Here, Jayawardane and colleagues further elucidate the nature of IMS by systematically recording repetitive nerve stimulation (RNS) patterns at the neuromuscular junction in patients poisoned with OPs.
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ورودعنوان ژورنال:
- PLoS Medicine
دوره 5 شماره
صفحات -
تاریخ انتشار 2008